2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130505
    N-Boc-PEG7-alcohol 1292268-13-3
    N-Boc-PEG7-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG7-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG7-alcohol
  • HY-140777
    Azido-PEG4-Boc 581066-04-8
    Azido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-Boc
  • HY-130417
    Tos-PEG4-acid 1453117-42-4
    Tos-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG4-acid
  • HY-140620
    m-PEG4-aldehyde 197513-96-5
    m-PEG4-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-aldehyde
  • HY-140463
    Fmoc-N-PEG23-acid 99.88%
    Fmoc-N-amido-PEG23-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-PEG23-acid
  • HY-141100
    Bis-PEG11-NHS ester 2883032-97-9 99.36%
    Bis-PEG11-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG11-NHS ester
  • HY-140028
    Propargyl-PEG4-Boc 1355197-66-8
    Propargyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Boc
  • HY-140886
    1,1,1-Trifluoroethyl-PEG2-propargyl 1835759-73-3
    1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    1,1,1-Trifluoroethyl-PEG2-propargyl
  • HY-138424
    m-PEG15-amine 2745717-94-4 99.91%
    m-PEG15-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG15-amine
  • HY-140709
    m-PEG-thiol (MW 20000)
    m-PEG-thiol (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-thiol (MW 20000)
  • HY-140826
    Bromoacetamido-PEG5-azide 1415800-37-1
    Bromoacetamido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromoacetamido-PEG5-azide
  • HY-140285
    DBCO-PEG9-amine 2353409-99-9
    DBCO-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG9-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG9-amine
  • HY-130445
    m-PEG3-CH2COOH 16024-60-5
    m-PEG3-CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG3-CH2COOH
  • HY-128803
    Tos-PEG4-NH-Boc 1246999-33-6 ≥98.0%
    Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Tos-PEG4-NH-Boc
  • HY-132078
    Azido-PEG7-acid
    Azido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-acid
  • HY-130457
    m-PEG4-MS 130955-37-2
    m-PEG4-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG4-MS
  • HY-140059
    Propargyl-PEG3-methane 89635-82-5 98.0%
    Propargyl-PEG3-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-methane
  • HY-130595
    Benzyl-PEG4-acid 127457-64-1 98.0%
    Benzyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Benzyl-PEG4-acid
  • HY-141166
    TCO-PEG3-NHS ester 2141981-88-4
    TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG3-NHS ester
  • HY-120237
    m-PEG7-Amine 170572-38-0
    m-PEG7-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG7-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG7-Amine
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.